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Part of a motorway was closed following a crash involving multiple HGVs.
National Highways shut the M25 heading anticlockwise between Junction 17, for Rickmansworth, Hertfordshire, and Junction 16, for the M40 and Uxbridge, London, at about 12:00 BST.
Thames Valley Police said three lorries were involved and there were no significant injuries.
Drivers have been told the road could remain closed until 14:30 and to expect delays.
